A small number of cases of accelerated nodulosis have been reported in the literature it is unclear whether the development of accelerated nodulosis during methotrexate therapy is a drug-related side effect or is part of the natural history of the rheumatoid disease.
There can be several manifestation of methotrexate related lung changes.
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The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment results of a phase iib randomized, double-blind, placebo-controlled, dose-ranging trial.
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Methotrexate is indicated in the treatment of neoplastic disease, such as trophoblastic neoplasms and leukaemia, and the symptomatic treatment of severe recalcitrant disabling psoriasis which is not adequately responsive to other forms of therapy.
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